Impact of Caffeine on Mental Health and Cognitive Function
Keywords:
Psychoactive, stress-related symptoms genetically, caffeinism, cognitive function, brain's adenosine neurotransmitterAbstract
Coffee, tea, and energy drinks contain caffeine, a psychoactive chemical that is the most widely consumed drug in the world. It can change estrogen levels and cause anxiety, stress-related symptoms, and sleep problems. It is not advised for people with anxiety, insomnia, or digestive problems to consume caffeine because it is genetically influenced. Withdrawal symptoms and "caffeinism" symptoms can result from high dosages. In the general population, caffeine consumption is a moderate risk factor for drug use and mental health issues. The physiological effects of coffee and caffeine are similar; caffeine improves mood and cognitive function by blocking the brain's adenosine neurotransmitter and increasing the production of other neurotransmitters. In some situations, caffeine improves performance by increasing energy and alertness. High dosages, however, can result in "caffeinism," a mood disorder. Headaches, sleepiness, anxiety, and depression are some of the withdrawal symptoms. Withdrawal symptoms, a constant need to cut back on intake, and tolerance are indicators of clear caffeine dependence. Higher cerebral blood velocity, higher EEG theta, and lower beta 2 power are all linked to abstinence.
References
Abdoli, F., Davoudi, M., Momeni, F., Djafari, F., Dolatshahi, B., Hosseinzadeh, S., & Khalili, Z. (2023). Estimate the prevalence of daily caffeine consumption, caffeine use disorder, caffeine withdrawal and harm in Iran: A cross-sectional study. Research Square. https://doi.org/10.21203/rs.3.rs-3699710/v1
Abdoli, F., Davoudi, M., Momeni, F., Djafari, F., Dolatshahi, B., Hosseinzadeh, S., & Khalili, Z. (2024). Estimate the prevalence of daily caffeine consumption, caffeine use disorder, caffeine withdrawal and perceived harm in Iran: A cross-sectional study. Scientific Reports, 14(1), Article 7644. https://doi.org/10.1038/s41598-024-58496-8
Ágoston, C., Urbán, R., Richman, M. J., & Demetrovics, Z. (2018). Caffeine use disorder: An item-response theory analysis of proposed DSM-5 criteria. Addictive Behaviors, 81, 109–116. https://doi.org/10.1016/j.addbeh.2018.02.012
Agritelley, M. S., & Goldberger, J. J. (2021). Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal. Food and chemical toxicology, 153, 112228. https://doi.org/10.1016/j.fct.2021.112228
Alimyar, O., Nahiz, A., Monib, A. W., Baseer, A. Q., Hassand, M. H., Kakar, U. M., & Niazi, P. (2024). Coffee plant (caffeine): Examining its impact on physical and mental health. European Journal of Medical and Health Research, 2(2), 143–154. https://doi.org/10.59324/ejmhr.2024.2(2).16
Bertasi, R. A., Humeda, Y., Bertasi, T. G., Zins, Z., Kimsey, J., Pujalte, G., & Pujalte, G. G. (2021). Caffeine intake and mental health in college students. Cureus, 13(4), Article e14313. https://doi.org/10.7759/cureus.14313
Bird, E. T., Parker, B. D., Kim, H. S., & Coffield, K. S. (2024). Caffeine ingestion and lower urinary tract symptoms in healthy volunteers. Neurourology and Urodynamics, 24(7), 611–615. https://doi.org/10.1002/nau.20179
Brice, C. F., & Smith, A. P. (2002). Factors associated with caffeine consumption. International Journal of Food Sciences And Nutrition, 53(1), 55–64.
Caton, S., Chadwick, D., Chapman, M., Turnbull, S., Mitchell, D., & Stansfield, J. (2012). Healthy lifestyles for adults with intellectual disability: knowledge, barriers, and facilitators. Journal of Intellectual and Developmental Disability, 37(3), 248–259. https://doi.org/10.3109/13668250.2012.703645
Childs, E., Hohoff, C., Deckert, J., Xu, K., Badner, J., & De Wit, H. (2008). Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology, 33(12), 2791-2800.
Cholewa, K., Czarnek, K., Grzywacz, A., & Masiak, J. (2023). Energy drink use disorder—A review of the literature. Teka Komisji Prawniczej, 16(1), 21–31. https://doi.org/10.32084/tkp.5425
Clark, K. S., Coleman, C., Shelton, R., Heemstra, L. A., & Novak, C. M. (2019). Caffeine enhances activity thermogenesis and energy expenditure in rats. Clinical and Experimental Pharmacology and Physiology, 46(5), 475–482. https://doi.org/10.1111/1440-1681.13065
Czajkowski, N., Kendler, K. S., Torvik, F. A., Ystrom, E., Rosenström, T., Gillespie, N. A., & Reichborn-Kjennerud, T. (2021). Caffeine consumption, toxicity, tolerance and withdrawal: Shared genetic influences with normative personality and personality disorder traits. Experimental and Clinical Psychopharmacology, 29(6), 650–660. https://doi.org/10.1037/pha0000429
Czchowski, K., Kościołek, A., Misiak, J., Kościołek, D., Kępczyk, M., Ojdana, M., ... & Tokarski, M. (2024). The frequency of coffee consumption in the Slavic population and its impact on health. Journal of Education, Health and Sport, 62, 46–60. https://doi.org/10.12775/JEHS.2024.62.003
de Paula, J., & Farah, A. (2021). Caffeine consumption through coffee: Content in the beverage, metabolism, health benefits and risks. Beverages, 5(2), 37. https://doi.org/10.3390/beverages5020037
Erdős, Á. (2023). Coffee, energy drinks consumption and caffeine use disorder among law enforcement college students in Hungary. European Journal of Mental Health, 18, 1–12. https://doi.org/10.5708/EJMH.18.2023.0008
Gaspar, C., Rocha, C., Balteiro, J., & Santos, H. (2024). Effects of caffeine on cerebral blood flow. Nutrition, Article e112217. https://doi.org/10.1016/j.nut.2023.112217
Gilliland, K., & Andress, D. (2022). Ad lib caffeine consumption, symptoms of caffeinism, and academic performance. American Journal of Psychiatry, 138(4), 512–514. https://doi.org/10.1176/ajp.138.4.512
Graham, T. E. (2020). Caffeine and exercise: Metabolism, endurance and performance. Sports Medicine.
Greden, J. F. (2021). Anxiety or caffeinism: A diagnostic dilemma. American Journal of Psychiatry, 131, 1089–1092. https://doi.org/10.1176/ajp.131.10.1089
Grosso, G., Micek, A., Castellano, S., Pajak, A., & Galvano, F. (2016). Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies. Molecular Nutrition & Food Research, 60(1), 223–234. https://doi.org/10.1002/mnfr.201500620
Hohoff, C., Domschke, K., Schwarte, K., et al. (2009). Sympathetic activity relates to adenosine A(2A) receptor gene variation in blood-injury phobia. Journal of Neural Transmission, 116, 659–666. https://doi.org/10.1007/s00702-008-0089-5
Isa, Z. M., Anuar, A. A., Azmi, A. D., Selvan, S. T., Hisham, N. S., & Qing, Y. Z. (2021). Does caffeine intake influence mental health of medical students? Malaysian Journal of Public Health Medicine, 21(2), 22–28. https://doi.org/10.37268/mjphm/vol.21/no.2/art.626
Jahrami, H., Al-Mutarid, M., Penson, P. E., Al-Islam Faris, M. E., Saif, Z., & Hammad, L. (2020). Intake of caffeine and its association with physical and mental health status among university students in Bahrain. Foods, 9, Article 473. https://doi.org/10.3390/foods9040473
Jee, H. J., Lee, S. G., Bormate, K. J., & Jung, Y. S. (2020). Effect of caffeine consumption on the risk for neurological and psychiatric disorders: Sex differences in human. Nutrients, 12(10), Article 3080. https://doi.org/10.3390/nu12103080
Kawachi, I., Willett, W. C., Colditz, G. A., Stampfer, M. J., & Speizer, F. E. (2019). A prospective study of coffee drinking and suicide in women. Archives of Internal Medicine, 156, 521–525. https://doi.org/10.1001/archinte.1996.00440050067008
Kendler, K. S., Myers, J., & Gardner, C. O. (2017). Caffeine intake, toxicity and dependence and lifetime risk for psychiatric and substance use disorders: An epidemiologic and co-twin control analysis. Psychological Medicine, 36, 1717–1725. https://doi.org/10.1017/S0033291706008622
Lara, D. R. (2010). Caffeine, mental health, and psychiatric disorders. Journal of Alzheimer’s Disease, 20(S1), S239–S248. https://doi.org/10.3233/JAD-2010-1378
Larsson, S. C., & Markus, H. S. (2018). Does treating vascular risk factors prevent dementia and Alzheimer’s disease? A systematic review and meta-analysis. Journal of Alzheimer’s Disease, 64(2), 657–668. https://doi.org/10.3233/JAD-180288
Liu, C., Wang, L., Zhang, C., Hu, Z., Tang, J., Xue, J., & Lu, W. (2024). Caffeine intake and anxiety: A meta-analysis. Frontiers in Psychology, 15, Article 1270246. https://doi.org/10.3389/fpsyg.2024.1270246
Marmorstein, N. R. (2016). Energy drink and coffee consumption and psychopathology symptoms among early adolescents: Cross-sectional and longitudinal associations. Journal of Caffeine Research, 6(2), 64–72. https://doi.org/10.1089/jcr.2015.0018
Masdrakis, V. G., Papakostas, Y. G., Vaidakis, N., Papageorgiou, C., & Pehlivanidis, A. (2008). Caffeine challenge in patients with panic disorder: Baseline differences between those who panic and those who do not. Depression and Anxiety, 25, E72–E79. https://doi.org/10.1002/da.20333
Nehlig, A. (2025). What Are the Effects of Coffee at the Different Levels of the Digestive Tract? I M. Banach & S. Surma (Eds.), The Link Between Coffee and Health, 193–234. Springer Publications.
Nowaczewska, M., Wiciński, M., & Kaźmierczak, W. (2020). The ambiguous role of caffeine in migraine headache: from trigger to treatment. Nutrients, 12(8), 2259
O'Callaghan, F., Muurlink, O., & Reid, N. (2018). Effects of caffeine on sleep quality and daytime functioning. Risk Management and Healthcare Policy, 11, 263–271. https://doi.org/10.2147/RMHP.S156404
Penolazzi, B., Natale, V., Leone, L., & Russo, P. M. (n.d.). Individual differences affecting caffeine intake: Analysis of consumption behaviours for different times of day and caffeine sources.
Schwartzhaupt, A. W., Lara, D. R., Hirakata, V. N., Schuch, A., Almeida, E., Silveira, L., Caldieraro, M. A., & Fleck, M. P. (2019). Does caffeine change the effect of sleep deprivation on moderate to severe depressed patients? Journal of Affective Disorders, 112, 279–283. https://doi.org/10.1016/j.jad.2008.04.015
Searle, W. (2024). Effects of caffeine on muscle strength: Influence of genetics (Doctoral dissertation, University of Kent).
Sigmon, S. C., Peck, K. R., Batchelder, S. R., Badger, G. J., Heil, S. H., & Higgins, S. T. (2023). Technology-assisted buprenorphine treatment in rural and nonrural settings: Two randomized clinical trials. JAMA Network Open, 6(9), e2331910.
Silverman, W. K., Marin, C. E., Rey, Y., Kurtines, W. M., Jaccard, J., & Pettit, J. W. (2019). Group-versus parent-involvement CBT for childhood anxiety disorders: Treatment specificity and long-term recovery mediation. Clinical Psychological Science, 7(4), 840–855. https://doi.org/10.1177/2167702619830404
Szerej, K., Dorobek, W., Stankiewicz, K., & Świeczkowski-Feiz, J. (2024). The role of caffeine in enhancing physical performance: from metabolism to muscle function. Journal of Education, Health and Sport, 59, 158–165. https://doi.org/10.12775/JEHS.2024.59.010
Tearney, C. (2024). CNS stimulants. In T. Aarnes, & P. Lerche (Eds.), Pharmacology in veterinary anesthesia and analgesia (pp. 177–182). Wiley Online Library. https://doi.org/10.1002/9781118975169.ch14
Thayer, R. E. (2018). The origin of everyday moods: Managing energy, tension, and stress. Oxford University Press.
Torabynasab, K., Shahinfar, H., Payandeh, N., & Jazayeri, S. (2023). Association between dietary caffeine, coffee, and tea consumption and depressive symptoms in adults: A systematic review and dose-response meta-analysis of observational studies. Frontiers in Nutrition, 10, Article 1051444. https://doi.org/10.3389/fnut.2023.1051444
van Dam, R. M., Hu, F. B., & Willett, W. C. (2020). Coffee, caffeine, and health. New England Journal of Medicine, 383(4), 369–378. https://doi.org/10.1056/NEJMra1816604
Yokomukai, Y., Cowart, B. J., & Beauchamp, G. K. (2022). Individual differences in sensitivity to bitter-tasting substances. Chemical Senses, 18(6), 669–681. https://doi.org/10.1093/chemse/18.6.669
